It is illegal to keep a skunk as a pet.

The Law Explained

While some exotic animal lovers enjoy keeping domesticated, de-scented skunks, local health codes vehemently disagree with the practice. Skunks are prime vectors for rabies, and there is no approved rabies vaccine for them in the state. To protect the college-town population from disease and foul odors, Clemson firmly outlawed them as household companions.